BIM 283: Advanced Design of Experiments for Biomedical Engineers
Winter 2025

Course Syllabus

Instructor: David M. Rocke (dmrocke at ucdavis.edu)

Announcements

Class will be held in 1060 Bainer, Tuesdays and Thursdays, 10:00–11:50
The lecture slides will be posted

Class January 7 and 9 will be by Zoom
Office Hours week of Jan 6 will be by Zoom by request

R Resources

Introductory Statistics with R (Textbook: ISwR)

https://cran.r-project.org/bin/windows/base/

https://www.bigbookofr.com

https://www.rstudio.com/products/rstudio/

https://rstudio-education.github.io/hopr/starting.html

Textbook:

Statistics for Experimenters, Second Edition.
Box, GEP, Hunter, JS, and Hunter, WG, Wiley, 2005.

Class Notes:

January 7. 2025 (Zoom)
Reading:
BHH Chapter 1
Presentation: Lecture 1: Introduction to Experimental Design
Note: Class this week will be by Zoom. Link to follow.

Install R and (optionally) R Studio (links above)
Practice using ISwR or the R Studio Education link

January 9, 2025 (Zoom)
Reading:
BHH Chapter 1
Presentation: Lecture 2: Introduction to Experimental Design (part 2)
Homework: See end of slides for Lecture 2—submit code and results. Due 1/16/25.
Note: Class this week will be by Zoom. Link to follow.

January 14, 2025
Reading:
BHH Chapter 2
Presentation: Lecture 3: R Basics
Homework: See end of slides—Due 1/23/25 (Does not have to be handed in.)

January 16, 2025
Reading:
BHH Chapter 2
Presentation: Lecture 4: Regression and Calibration
Homework:

January 21, 2025
Reading:

Presentation: Lecture 5: Introduction to Assays

January 23, 2025
Reading:

Presentation: Lecture 6: Measurement and Analytical Error
Homework: Homework 3: see slides 24 and 25—Due 1/30/25

Currie et al. (1995)
Rocke and Lorenzato (1995)
Wilson, Rocke, Durbin, and Kahn (2004)
zinc data

January 28, 30, 2025
Reading:
BHH, Chapters 3 and 4.
Presentation: Lecture 7: Fully Randomized and Randomized Block Designs
Homework: HW 4, due 2/6/25

BHH2 R Package Reference Manual
BHH2 R Package Vignette
BsMD R Package Reference Manual
BHH Data Sets (zip file)

February 4, 2025
Reading:

Presentation: Lecture 8: PCR, Immunoassays, RNA-Seq, Mass Spectrometry
Homework: Homework 3 Comments

February 6, 2024
Reading:
BHH, Chapter 5.
Presentation: Lecture 9: Factorial Designs at Two Levels
Homework: HW 5, due 2/28/25

Prat and Tort (1990)

February 11, 2024
Reading:
BHH, Chapter 5.
Presentation: Lecture 9: Factorial Designs at Two Levels
Homework: HW 5, due 2/28/25
Homework: Homework 4 Comments

February 13, 2024
Midterm Exam

February 18, 20, 25, 2025
Reading:
BHH, Chapter 6.
Presentation: Lecture 10: Fractional Factorial Designs
Midterm Slides

Hellstrand (1989)
Quinlan (1985)

February 25, 2025
Take Home Final Exam: due 3/14/2025

March 6, 2025
Reading:
BHH, Chapter 8.
Presentation: Lecture 11: Transformation and Variance
Homework:

March 11, 2025
Reading:

Presentation: Lecture 12: Multiple Comparisons
Homework: