BIM 283: Advanced Design of Experiments for Biomedical Engineers
Winter 2024

Course Syllabus

Instructor: David M. Rocke (dmrocke at ucdavis.edu)
TA: Brittany Lemmon (blemmon at ucdavis.edu)

Announcements

The lecture part of class will be roughly 10:00am–11:20 am
The lab component will be homework help and Q&A with Brittany, roughly 11:20am–11:50am
The lecture slides will be posted

R Resources

Introductory Statistics with R (Textbook: ISwR)

https://cran.r-project.org/bin/windows/base/

https://www.bigbookofr.com

https://www.rstudio.com/products/rstudio/

https://rstudio-education.github.io/hopr/starting.html

Textbook:

Statistics for Experimenters, Second Edition.
Box, GEP, Hunter, JS, and Hunter, WG, Wiley, 2005.

Class Notes:

January 9. 2024
Reading:
BHH Chapter 1
Presentation: Lecture 1: Introduction to Experimental Design
Homework:

January 11, 2024
Reading:
BHH Chapter 1
Presentation: Lecture 2: Introduction to Experimental Design (part 2)
Homework: See end of slides for Lecture 2—submit code and results. Due 1/23/24.

January 16, 2024
Reading:
BHH Chapter 2
Presentation: Lecture 3: R Basics
Homework: See end of slides—Due 1/25/24 (Does not have to be handed in.)

January 18, 2024
Reading:
BHH Chapter 2
Presentation: Lecture 4: Regression and Calibration
Homework:

January 23, 2024
Reading:

Presentation: Lecture 5: Introduction to Assays

January 25, 2024
Reading:

Presentation: Lecture 6: Measurement and Analytical Error
Homework: See slides 24 and 25—Due 2/1/24

Currie et al. (1995)
Rocke and Lorenzato (1995)
Wilson, Rocke, Durbin, and Kahn (2004)
zinc data

January 30, 2024
Reading:

Presentation: Lecture 7: PCR, Immunoassays, and RNA-Seq
Homework:

February 1, 2024
Reading:

Presentation: Lecture 8: Mass Spectrometry for Metabolomics and Proteomics
Homework:

February 6, 8, 2024
Reading:
BHH, Chapters 3 and 4.
Presentation: Lecture 9: Fully Randomized and Randomized Block Designs
Homework: HW 4, due 2/20/24

BHH2 R Package Reference Manual
BHH2 R Package Vignette
BsMD R Package Reference Manual
BHH Data Sets (zip file)

February 13, 15, 2024
Reading:
BHH, Chapter 5.
Presentation: Lecture 10: Factorial Designs at Two Levels
Homework: HW 5, due 2/27/24

Prat and Tort (1990)

February 20, 22, 27, 2024
Reading:
BHH, Chapter 6.
Presentation: Lecture 11: Fractional Factorial Designs
Homework: HW6, due 3/12/2024

Hellstrand (1989)
Quinlan (1985)

February 29, 2024
Reading:
BHH, Chapter 8.
Presentation: Lecture 12: Transformation and Variance
Homework:

March 5, 2024
Reading:

Presentation: Lecture S1: Introduction to Survival Analysis
Homework:

March 7, 12, 2024
Reading:

Presentation: Lecture S2: Survival Data and Methods
Homework:

March 14, 2024
Reading:

Presentation: Lecture S3: Survival Regression
Homework: